Yehao Luo, Master,Guangxi university of Traditional Chinese Medicine,Nanning, China; Master,College of Pharmacy, Minzu University of China, Beijing, China

Donghan Xu, Master,Macau University of Science and Technology,Macau, PR China

Luqiu Wei, Master,Guangxi university of Traditional Chinese Medicine,Nanning, China

Geer Chen, Master,Guangxi university of Traditional Chinese Medicine,Nanning, China; Master,Macau University of Science and Technology,Macau, PR China

Yuzhou Pang, Guangxi university of Traditional Chinese Medicine, PR China

Abstract
Systemic lupus erythematosus(SLE),known as lupus,is a chronic autoimmune disease and there is no cure for SLE.The western medication can improve syndromes to some extent,however,severe adverse drug reactions appear at the same time.Recently,it is confirmed that Chinese medicine also can have an excellent clinical efficacy on SLE.A meta-analysis was performed by using RevMan 5.3.A total of 9 randomized controlled trials, which involved 775 participants, met the inclusion criteria in this meta-analysis.It showed that the combination of Chinese and western medicine in the treatment of systemic lupus erythematosus(SLE) clearly improved the clinical efficacy compared with thecontrol group[OR=2.71,95%CI(1.75,4.19),P<0.00001],the levels of C3 increased[MD=0.11, 95%CI(0.04,0.17),P=0.002],the Hb levels increased [MD=7.02,95%CI(4.28,9.77),P<0.00001], the WBC levels increased [MD = 0.88, 95% CI (0.70,1.06),p<0.00001].In this study,the treatment of combination of Chinese and western medicine on SLE achieves more excellent clinical efficacy compared with the individual western medication therapy.

Keywords
Systemic Lupus Erythematosus, combination of Chinese and western medicine,meta-analysis, systemic review

Cite this paper
Yehao Luo, Donghan Xu, Luqiu Wei, Geer Chen, Yuzhou Pang, Clinical Efficacy of the treatment of combination of Chinese and western medicine on Systemic Lupus Erythematosus:A Meta-analysis following the PRISMA , SCIREA Journal of Clinical Medicine. Volume 6, Issue 1, February 2021 | PP. 7-23.

References

[ 1 ]	"Handout on Health:Systemic Lupus Erythematosus".www.niams.nih.gov.February 2015.Archivedfrom the original on 17 June 2016.Retrieved 12 June 2016.
[ 2 ]	Lisnevskaia,L;Murphy,G;Isenberg,D(22 November 2014)."Systemic lupus erythematosus".Lancet.384(9957):187888.CiteSeerX10.1.1.1008.5428.doi:10.1016/s0140-6736(14)60128-8.PMID24881804.
[ 3 ]	Vasudevan AR,Ginzler EM(August 4,2009)."Established and novel treatments for lupus".The Journal of Musculoskeletal Medicine.26(8).[permanent dead link]
[ 4 ]	Xing Xiaozhong,Zheng Luping,Dong Yun.The influence of integrated traditional Chinese and Western medicine on blood routine of patients with systemic lupus erythematosus with blood system damage[J].New Chinese Medicine, 2016,48(07):90-91.
[ 5 ]	Liu Shuzhen,Liu Guangxi,Liu Sanyun et al.Therapeutic effect of integrated traditional Chinese and Western medicine on systemic lupus erythematosus[J].Chinese Journal of Integrated Traditional and Western Medicine,2008(11):994-997.
[ 6 ]	Yang Xiaotong,Liu Xiaoya.Therapeutic effect of 72 cases of systemic lupus erythematosus treated with integrated traditional Chinese and Western medicine[J].New Chinese Medicine,2008(03):43-44+8.
[ 7 ]	Song Wenping.Clinical Observation on 34 Cases of Systemic Lupus Erythematosus Treated by Integrative Chinese and Western Medicine[J].Hebei Traditional Chinese Medicine,2010,32(01):69-70.
[ 8 ]	Mao Hui.Therapeutic effect of integrated traditional Chinese and Western medicine on systemic lupus erythematosus[J].Chinese Medicine Introduction,2011,8(06):81+83.
[ 9 ]	Zou Libin.Clinical Observation and Pathogenesis of Systemic Lupus Erythematosus Treated by Integrative Chinese and Western Medicine[J].Journal of Hubei University of Traditional Chinese Medicine,2013,15(04):25-27.
[ 10 ]	Wang Ye,Xu Hui.Treatment of 56 cases of systemic lupus erythematosus with integrated traditional Chinese and Western medicine[J].Henan Traditional Chinese Medicine,2016,36(09):1603-1605.
[ 11 ]	OU Daming.Therapeutic efficacy and safety of integrated Chinese and Western medicine in the treatment of systemic lupus erythematosus[A].Chinese Journal of Hypertension,China.Journal of Translational Medicine and Integrated Medicine,Comprehensive Papers[C].China Hypertension Magazine:China Hypertension Magazine,2015:2.
[ 12 ]	ZHU Zhen,ZHANG Shiqin,WANG Yue.Clinical study on 32 cases of systemic lupus erythematosus treated with combination of traditional Chinese and western medicine[J].Jiangsu Journal of Traditional Chinese Medicine,2012,44(11):25-26.
[ 13 ]	Syuto T,Shimizu A,Takeuchi Y,et al.(February 2009)."Association of antiphosphatidylserine/prothrombin antibodies with neuropsychiatric systemic lupus erythematosus".Clin.Rheumatol.28(7):841 5.doi:10.1007/s10067-009-1123-1.PMID19224124.
[ 14 ]	Calderaro,DC;Ferreira,GA(May 2012)."Presentation and prognosis of shrinking lung syndrome in systemic lupus erythematosus:report of four cases".Rheumatology International.32(5):1391–6.doi:10.1007/s00296-011-1863-5.PMID21431288.
[ 15 ]	Kasama,T;Maeoka,A;Oguro,N(2016)."Clinical Features of Neuropsychiatric Syndromes in Systemic Lupus Erythematosus and Other Connective Tissue Diseases".Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders.9: CMAMD.S37477.doi:10.4137/CMAMD.S37477.PMC4718090.PMID26819561.