Red wine and Resveratrol, their effect on human health
DOI: 10.54647/agriculture210323 107 Downloads 151298 Views
Author(s)
Abstract
Based on several in vitro and in vivo studies, it appears that a certain amount of daily consumption of wine can prevent to some degree various chronic diseases. This is mainly due to the presence and number of important antioxidants in red wine. Wine polyphenols, especially resveratrol, anthocyanins and catechins, are the most effective antioxidants in wine. Resveratrol is thought to help prevent cardiovascular disease by neutralizing free radicals but also protecting the nervous system and other organs. The term "French Paradox" is used to describe the relatively low incidence of cardiovascular disease in the French population despite the high consumption of fats. However, in the case of heavy wine consumption, ethanol limits the benefits of the action of polyphenols in wine. From the literature review it appears that the combined- synergistic effect of wine phenols is superior to their individual action. Resveratrol requires red wine polyphenols for optimal antioxidant activity. Research has shown some positive effects, but several more studies are needed to draw safe conclusions as not many clinical trials have been performed in humans. Advances in technology have enabled new techniques to recover the valuable ingredients of red wine from by-products of vinification for their use in pharmacy and cosmetology. Consumers are now looking for natural products to enhance their health and beauty. The uses of wine ingredients give new perspectives for their utilization in the pharmaceutical industry and cosmetology.
Keywords
Red Wine, Resveratrol, Polyphenols, French paradox, Free radicals, Antioxidants, Alzheimer ’s disease
Cite this paper
Karampatea Aikaterini, Konstantinidou Parthena,
Red wine and Resveratrol, their effect on human health
, SCIREA Journal of Agriculture.
Volume 8, Issue 1, February 2023 | PP. 45-96.
10.54647/agriculture210323
References
[ 1 ] | Agarwal, B., & Baur, J. A. (2011). Resveratrol and life extension. Annals of the New York Academy of Sciences, 1215, 138–143. https://doi.org/10.1111/j.1749-6632.2010.05850.x |
[ 2 ] | Al-Awwadi et al. (2004) “Red Wine Polyphenols Alone or in Association with Ethanol Prevent Hypertension, Cardiac Hypertrophy, and Production of Reactive Oxygen Species in the Insulin-Resistant Fructose-Fed Rat”. Available at: https://pubs.acs.org/doi/10.1021/jf049295g (Accessed: 3 February 2022). |
[ 3 ] | Anagnostakis, H., (2006) in Wine: Culture and Society. Athens: National Research Foundation, pp.39-67. |
[ 4 ] | Anselm E, et al. (2007). Grape juice causes endothelium dependent relaxation via a redox-sensitive Src- and Akt dependent activation of eNOS. Cardiovasc Res. 2007; 73:404–413 |
[ 5 ] | Artero, A. et al.(2015) “The impact of moderate wine consumption on health”. Maturitas, 80(1), pp.3-13. |
[ 6 ] | Aviram, M. and Fuhrman, B. (2002) "Wine Flavonoids Protect against LDL Oxidation and Atherosclerosis", Annals of the New York Academy of Sciences |
[ 7 ] | Azat Aziz, M., Shehab Diab, A. and Abdulrazak Mohammed, A. (2019) "Antioxidant Categories and Mode of Action", Antioxidants. doi: 10.5772/intechopen.83544 |
[ 8 ] | Baile, et al (2011). Effect of resveratrol on fat mobilization. Annals of the New York Academy of Sciences, 1215, 40–47. https://doi.org/10.1111/j.1749-6632.2010.05845.x |
[ 9 ] | Ballard R.D. et al. (2002), Iron Age Shipwrecks in Deep Water off Ashkelon, Israel, American Journal of Archaeology 2002 106:2, 151-168, Web.mit.edu. Available at: http://web.mit.edu/deeparch/www/publications/papers/BallardEtAl2002.pdf (Accessed: 20 January 2022). |
[ 10 ] | Barnard, H. et al. (2011), «Chemical evidence for wine production around 4000 BCE in the Late Chalcolithic Near Eastern highlands», Journal of Archaeological Science, Volume 38, Issue 5,2011(Accessed: 20 January 2022). |
[ 11 ] | Beher, D., et al. (2009). Resveratrol is not a direct activator of SIRT1 enzyme activity. Chemical Biology and Drug Design 74(6):619-24. https://pubmed.ncbi.nlm.nih.gov/19843076/ |
[ 12 ] | Berger, K. et al. (1999) "Light-to-Moderate Alcohol Consumption and the Risk of Stroke among U.S. Male Physicians", New England Journal of Medicine, 341(21), pp. 1557-1564. Available at: https://pubmed.ncbi.nlm.nih.gov/10564684/ (Accessed: 2 February 2022). |
[ 13 ] | Bertelli AA. (2007) “Wine, research and cardiovascular disease: instructions for use. Atherosclerosis”. Dec;195(2):242-7. doi: 10.1016/j.atherosclerosis.2007.04.006. Epub 2007 May 24. PMID: 17531243 |
[ 14 ] | Bhatt, J., Thomas, S. and Nanjan, M. (2012) "Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus", Nutrition Research, 32(7), pp. 537-541. doi: 10.1016/j.nutres.2012.06.003. https://pubmed.ncbi.nlm.nih.gov/22901562/ |
[ 15 ] | Bhattacharya, S. and Sherje, A. (2020) "Development of resveratrol and green tea sunscreen formulation for combined photoprotective and antioxidant properties", https://www.sciencedirect.com/science/article/pii/S1773224720312892?via%3Dihub#undfig1 |
[ 16 ] | Carollo, C., Presti, R. and Caimi, G. (2007) "Wine, Diet, and Arterial Hypertension", Angiology, 58(1), pp. 92-96. doi: 10.1177/0003319706295478. |
[ 17 ] | Caruana, M., Cauchi, R. and Vassallo, N. (2016) "Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer’s and Parkinson’s Disease", Frontiers in Nutrition, 3. doi: 10.3389/fnut.2016.00031. https://www.frontiersin.org/articles/10.3389/fnut.2016.00031/full |
[ 18 ] | Cavallini, G. et al. (2015) "Resveratrol requires red wine polyphenols for optimum antioxidant activity", The journal of nutrition, health & aging, 20(5), pp. 540-545. doi: 10.1007/s12603-015-0611-z. |
[ 19 ] | Chen, S. et al. (2019) "The influences of red wine in phenotypes of human cancer cells", Gene, 702, pp. 194-204. doi: 10.1016/j.gene.2018.10.049. |
[ 20 ] | Chiva-Blanch, G. and Badimon, L. (2019) "Benefits and Risks of Moderate Alcohol Consumption on Cardiovascular Disease: Current Findings and Controversies", Nutrients, 12(1), p. 108. doi: 10.3390/nu12010108. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020057/ |
[ 21 ] | Cohen, S. et al. (1993) "Smoking, alcohol consumption, and susceptibility to the common cold.", American Journal of Public Health, 83(9), pp. 1277-1283. doi: 10.2105/ajph.83.9.1277. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1694990/ (Accessed: 25 January 2022). |
[ 22 ] | Crawford, G. (2020) “Wine & Medicine: An Enduring Historical Association” Available at: https://www.guildsomm.com/public_content/features/articles/b/geoffrey-crawford/posts/wine-and-medicine (Accessed: 21 January 2022). |
[ 23 ] | De Groote, et al. (2012). Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects. Annals of nutrition & metabolism, 61(1), 15–24. https://doi.org/10.1159/000338634 |
[ 24 ] | Doll, R. (2004) "Mortality in relation to alcohol consumption: a prospective study among male British doctors", International Journal of Epidemiology, 34(1), pp. 199-204. doi: 10.1093/ije/dyh369. |
[ 25 ] | Domínguez-López, I. et al. (2021) "Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol", Nutrients, 13(8), p. 2883. doi: 10.3390/nu13082883 https://pubmed.ncbi.nlm.nih.gov/34445043/ |
[ 26 ] | Dourtoglou V.G., Makris D.P., Bois-Dounas F., Zonas C. (1999) Trans-resveratrol concentration in wines produced in Greece. Journal of Food Composition and Analysis 12:227-233 PubMed (23871038) (2022) Available at: http://users.teiath.gr/vdourt/Trans-Resveratrol%20Concentration%20in%20Wines%20Produced%20in%20Greece.pdf (Accessed: 16 January 2022). |
[ 27 ] | Fischer-Posovszky, et al. (2010). Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. The American journal of clinical nutrition, 92(1), 5–15. https://doi.org/10.3945/ajcn.2009.28435 |
[ 28 ] | Fragopoulou, E. and Antonopoulou, S. (2020) "The French paradox three decades later: Role of inflammation and thrombosis", Clinica Chimica Acta, 510, pp. 160-169. doi: 10.1016/j.cca.2020.07.013. https://pubmed.ncbi.nlm.nih.gov/32653485/ |
[ 29 ] | Fraser-Bell, S., et al. (2005) "Smoking, Alcohol Intake, Estrogen use, and Age-Related Macular Degeneration in Latinos: The Los Angeles Latino Eye Study." American Journal of Ophthalmology”, pp. 79-87. SCOPUS, www.scopus.com, doi: 10.1016/j.ajo..08.024 |
[ 30 ] | Freitas et al. (2015). Trans-resveratrol and beta-carotene from sunscreens penetrate viable skin layers and reduce cutaneous penetration of UV-filters. International Journal of Pharmaceutics, 484 (1-2): 131-137. https://www.sciencedirect.com/science/article/pii/S0378517315001805 |
[ 31 ] | Friedman, M., Henika, P. and Levin, C. (2015) "Antimicrobial activities of red wine-based formulations containing plant extracts against Escherichia coli O157:H7 and Salmonella enterica serovar Hadar", Food Control, 50, pp. 652-658. doi: 10.1016/j.foodcont.2014.10.005 |
[ 32 ] | Gavia-García, G. et al. (2021) "Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging", Biology, 10(4), p. 253. doi: 10.3390/biology10040253.. |
[ 33 ] | Gligorijević, N. et al. (2021) "Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability", Molecules, 26(10), p. 2834. doi: 10.3390/molecules26102834 |
[ 34 ] | Gresele, P. et al. (2011) "Effects of resveratrol and other wine polyphenols on vascular function: an update", The Journal of Nutritional Biochemistry, 22(3), pp. 201-211. doi: 10.1016/j.jnutbio.2010.07.004 |
[ 35 ] | Grønbæk, M. et al.(2000) "Type of Alcohol Consumed and Mortality from All Causes, Coronary Heart Disease, and Cancer", Annals of Internal Medicine, 133(6), p. 411. doi: 10.7326/0003-4819-133-6-200009190-00008 . |
[ 36 ] | Hansen, A. et al. (2005) "Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease", European Journal of Clinical Nutrition, 59(3), pp. 449-455. doi: 10.1038/sj.ejcn.1602107. https://pubmed.ncbi.nlm.nih.gov/15674304 |
[ 37 ] | Harman, D. (1956) "Aging: A Theory Based on Free Radical and Radiation Chemistry", Journal of Gerontology, 11(3), pp. 298-300. doi: 10.1093/geronj/11.3.298 (Accessed: 2 November 2021) |
[ 38 ] | Harvard Health (2013). Ask the doctor: Why does alcohol affect women differently? - Available at: https://www.health.harvard.edu/womens-health/why-does-alcohol-affect-women-differently (Accessed: 23 September 2021). |
[ 39 ] | Hines, E. (2001) "Moderate alcohol consumption and coronary heart disease: a review", Postgraduate Medical Journal, 77(914), p. 747. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1742209/ (Accessed: 2 February 2022). |
[ 40 ] | Jackson, R. (2020) "Wine, food, and health", Wine Science, pp. 947-978. doi: 10.1016/b978-0-12-816118-0.00012-x. |
[ 41 ] | Jani, B. et al. (2021) "Association between patterns of alcohol consumption (beverage type, frequency and consumption with food) and risk of adverse health outcomes: a prospective cohort study", BMC Medicine, 19(1). doi: 10.1186/s12916-020-01878-2. |
[ 42 ] | Jernigan, al. (2000) “Towards a global alcohol policy: alcohol, public health and the role of WHO” Bulletin of the World Health Organization 2000, https://www.who.int/bulletin/archives/78%284%29491.pdf |
[ 43 ] | Jouanna, J., & Allies, N. (2012), «Greek Medicine from Hippocrates to Galen: Selected Papers (p. I–IV) » Brill. LEIDEN • BOSTON. Available at: http://www.jstor.org/stable/10.1163/j.ctt1w76vxr.1 (Accessed: 19 January 2022). |
[ 44 ] | Kakridis, I (1986) Greek mythology: Dodekatheo: Hephaistos, Dionysus, lesser and group gods, volume 4, Athens |
[ 45 ] | Kallithraka S., Arvanitoyannis I., El-Zajouli A., Kefalas P. (2001) The application of an improved method for trans-resveratrol to determine the origin of Greek red wines. Food Chemistry 75:355-363 |
[ 46 ] | Kikura, et al.. 2004, "The influence of red wine or white wine intake on platelet function and viscoelastic property of blood in volunteers", Platelets, vol. 15, no. 1, pp. 37-41 |
[ 47 ] | Klatsky, A.L. (2009) Alcohol and cardiovascular diseases. Expert Rev. Cardiovasc. Ther., 7, 499–506. (Accessed: 30 December 2021), |
[ 48 ] | Koh, A., Yasur-Landau, A. and Cline, E. (2014) "Characterizing a Middle Bronze Palatial Wine Cellar from Tel Kabri, Israel", PLoS ONE, 9(8), p. e106406. doi: 10.1371/journal.pone.0106406. |
[ 49 ] | Kourakou - Dragona, S. et al. (2006) Wine: Culture and Society. Edited by E. Grammatikopoulou. National Research Foundation (NRF) (Scientific society: Special educational events), Available at: https://hdl.handle.net/10442/7294. (Accessed: 7 December 2021). |
[ 50 ] | Kwon, J. et al. (2012) "Piceatannol, Natural Polyphenolic Stilbene, Inhibits Adipogenesis via Modulation of Mitotic Clonal Expansion and Insulin Receptor-dependent Insulin Signaling in Early Phase of Differentiation", Journal of Biological Chemistry, 287(14), pp. 11566-11578. doi: 10.1074/jbc.m111.259721. |
[ 51 ] | la Porte C, Voduc N, Zhang G, et al. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin, and alcohol (ethanol) in healthy human subjects. Clin Pharmacokinet. 2010;49(7):449-454. (PubMed) |
[ 52 ] | Le Roy, C. et al. (2020) "Red Wine Consumption Associated With Increased Gut Microbiota α-Diversity in 3 Independent Cohorts", Gastroenterology, 158(1), pp. 270-272.e2. doi: 10.1053/j.gastro.2019.08.024. |
[ 53 ] | Lusis, A. (2000) "Atherosclerosis", Nature, 407(6801), pp. 233-241. doi: 10.1038/35025203. |
[ 54 ] | Ma, H. et al. (2021) "Alcohol Consumption Levels as Compared With Drinking Habits in Predicting All-Cause Mortality and Cause-Specific Mortality in Current Drinkers", Mayo Clinic Proceedings, 96(7), pp. 1758-1769. doi: 10.1016/j.mayocp.2021.02.011. (Accessed: 30 December 2021 https://pubmed.ncbi.nlm.nih.gov/34218856/ |
[ 55 ] | Mallo, N., Lamas, J. and Leiro, J., 2013. Hydrogenosome Metabolism Is the Key Target for Antiparasitic Activity of Resveratrol against Trichomonas vaginalis. |
[ 56 ] | Mancuso, C. et al. (2012) "Natural substances and Alzheimer's disease: From preclinical studies to evidence-based medicine", Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1822(5), pp. 616-624. doi: 10.1016/j.bbadis.2011.09.004. |
[ 57 ] | McGovern, P. et al. (1996) "Neolithic resinated wine", Nature, 381(6582), pp. 480-481. doi: 10.1038/381480a0. |
[ 58 ] | McGovern, P. (1998) “Wine for Eternity,” Archaeology 51.4, 28-34. Available at: https://www.penn.museum/sites/biomoleculararchaeology/wp-content/uploads/2010/04/Archaeology-wine.pdf (Accessed: 10 October 2021). |
[ 59 ] | McGovern, P. (2009) Uncorking the Past: The Quest for Wine, Beer, and Other Alcoholic Beverages. Los Angeles: University of California Press; 2009, όπως αναφέρεται από τον Plotkin, M. , στο «The Ethnobotany of Wine as Medicine in the Ancient Mediterranean World - American Botanical Council» https://www.herbalgram.org/resources/herbalgram/issues/129/table-of-contents/hg129-feat-ethnobotany-wine/ (Accessed: 10 October 2021) |
[ 60 ] | McGovern, Patrick & Mirzoian, Armen & Hall, Gretchen. (2009). Ancient Egyptian herbal wines. Proceedings of the National Academy of Sciences of the United States of America. 106. 7361-6. 10.1073/pnas.0811578106. |
[ 61 ] | McGovern, P. et al. (2017) "Early Neolithic wine of Georgia in the South Caucasus", Proceedings of the National Academy of Sciences, 114(48), pp. E10309-E10318. doi: 10.1073/pnas.1714728114. (Accessed: 10 October 2021) |
[ 62 ] | Martín, S. et al. (2011) "Neuroprotective properties of Spanish red wine and its isolated polyphenols on astrocytes", Food Chemistry, 128(1), pp. 40-48. doi: 10.1016/j.foodchem.2011.02.074. https://www.sciencedirect.com/science/article/pii/S0308814611003517?via%3Dihub |
[ 63 ] | Menezes-Rodrigues, F. et al. (2021) "Cardioprotection stimulated by resveratrol and grape products prevents lethal cardiac arrhythmias in an animal model of ischemia and reperfusion", Acta Cirúrgica Brasileira, 36(3). doi: 10.1590/acb360306. |
[ 64 ] | Miziak, B., Błaszczyk, B. and Czuczwar, S. (2021) "Some Candidate Drugs for Pharmacotherapy of Alzheimer’s Disease", Pharmaceuticals, 14(5), p. 458. doi: 10.3390/ph14050458. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152728/ |
[ 65 ] | Moreno-Arribas, M. et al. (2020) "Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer’s Disease", Nutrients, 12(10), p. 3082. doi: 10.3390/nu12103082. |
[ 66 ] | Morselli, E., Maiuri, M., Markaki, M. et al. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 1, e10 (2010). https://doi.org/10.1038/cddis.2009.8 |
[ 67 ] | Movahed, A. et al. (2013) "Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients", Evidence-Based Complementary and Alternative Medicine, 2013, pp. 1-11. doi: 10.1155/2013/851267. |
[ 68 ] | Mukamal et al. ( 2006) Alcohol Consumption and Risk for Coronary Heart Disease in Men With Healthy Lifestyles, |
[ 69 ] | National Alcohol Action Plan 2019 - 2023 (2021). Available at: https://www.moh.gov.gr/articles/health/domes-kai-draseis-gia-thn-ygeia/antimetwpish-eksarthsewn/politikh-gia-thn-antimetwpish-twn-eksarthsewn/6307-ethniko-sxedio-drashs-gia-to-alkool-2019-2023 (Accessed: 23 October 2021). |
[ 70 ] | Norrie P., (2005) “Wine and Health Through the Ages, With Special Reference to Australia” A Thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy, School of Social Ecology and Lifelong Learning University of Western Sydney. Available at: https://www.drnorrie.info/downloads/drnorriethesis/DrNorrieThesis.pdf (Accessed: 19 January 2022). |
[ 71 ] | Nikolova, P. et al. (2018) "Wine as a medicine in ancient times", Scripta Scientifica Pharmaceutica, 5(2), p. 14. doi: 10.14748/ssp.v5i2.5610. Available at: https://journals.mu-varna.bg/index.php/ssp/article/view/5610 . (Accessed: 19 January 2022). |
[ 72 ] | Nooyens, A.C.J., et al. (2014), "Consumption of alcoholic beverages and cognitive decline at middle age: The Doetinchem cohort study", British Journal of Nutrition, vol. 111, no. 4, pp. 715-723. https://www.scopus.com/record/display.uri?eid=2-s2.0-84894069161&origin=inward |
[ 73 ] | Orgogozo, et al. , (1997) "Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area", Revue neurologique, 153(3), p. Available at: https://pubmed.ncbi.nlm.nih.gov/9296132/ (Accessed: 4 February 2022) |
[ 74 ] | Pacholec, M. et al. (2010) "SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1", Journal of Biological Chemistry, 285(11), pp. 8340-8351. doi: 10.1074/jbc.m109.088682. https://pubmed.ncbi.nlm.nih.gov/20061378/ |
[ 75 ] | Pagomenou, E. (2002), "Archaeological evidence for wine production during the Bronze Age in Crete." |
[ 76 ] | Patel, K.R., et al. (2010). Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Research 70(19): 7392–7399. https://patents.google.com/patent/WO2001091695A2/en |
[ 77 ] | Patra, S. et al. (2021) "Apoptosis and autophagy modulating dietary phytochemicals in cancer therapeutics: Current evidence and future perspectives", Phytotherapy Research, 35(8), pp. 4194-4214. doi: 10.1002/ptr.7082 |
[ 78 ] | Pezzuto, J. (2019) "Resveratrol: Twenty Years of Growth, Development and Controversy", Biomolecules & Therapeutics, 27(1), pp. 1-14. doi: 10.4062/biomolther.2018.176. |
[ 79 ] | Phillips, R., (2002). A short history of wine. New York: Ecco. Free Download, Borrow, and Available at: https://archive.org/details/shorthistoryofwi0000phil/page/n9/mode/2up (Accessed: 9 November 2021). |
[ 80 ] | Pignatelli, et al. (2002) , "Red and white wine differently affect collagen-induced platelet aggregation", Pathophysiology of Haemostasis and Thrombosis, vol. 32, no. 5-6, pp. 356-358. |
[ 81 ] | Pignatelli, P., et al. (2006) Polyphenols synergistically inhibit oxidative stress in subjects given red and white wine. Atherosclerosis, 188(1), pp.77-83. (Accessed: 9 November 2021). |
[ 82 ] | Plotkin, M., (2021) “The Ethnobotany of wine of as Medicine in the Ancient Mediterranean World, The Journal of the American Botanical Council, ISSUE: 129, Sept 2021, Page: 56-71(Accessed: 9 November 2021). |
[ 83 ] | Potter, G., Patterson, L., Wanogho, E. et al. The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. Br J Cancer 86, 774–778 (2002). https://doi.org/10.1038/sj.bjc.6600197 |
[ 84 ] | Poulsen, M. et al. (2013) "High-Dose Resveratrol Supplementation in Obese Men", Diabetes, 62(4), pp. 1186-1195. doi: 10.2337/db12-0975. https://pubmed.ncbi.nlm.nih.gov/23193181/ |
[ 85 ] | Poulaki-Padermali, E. (2022) The Oinurgika, Olympusarchaeology.gr. Available at: http://olympusarchaeology.gr/index.php/2014-04-07-07-10-16/2014-04-15-07-28-20/2014-04-15-07-30-00 /2014-04-15-08-17-54/69-2014-04-14-08-32-07 (Accessed: 22 January 2022). |
[ 86 ] | Pratt, P C, and R T Vollmer. “The beneficial effect of alcohol consumption on the prevalence and extent of centrilobular emphysema. A retrospective autopsy analysis.” Chest vol. 85,3 (1984): 372-7. doi:10.1378/chest.85.3.372 |
[ 87 ] | Puspitasari Y., Schwarz L. and Camici G. (2021) Affiliations"Role of lifespan-regulating genes in age-related cardiovascular disease" Available at: https://cardiovascmed.ch/article/doi/CVM.2021.w10055 (Accessed: 25 January 2022). |
[ 88 ] | Qureshi, S.A (2014) “Food items contributing most to variation in antioxidant intake; a cross-sectional study among Norwegian women”. BMC Public Health 2014, 14. https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-14-45 |
[ 89 ] | Reale et al. (2020) A. Relationship of Wine Consumption with Alzheimer's Disease. Nutrients. 2020;12(1):206. Published 2020 Jan 13. doi:10.3390/nu12010206 |
[ 90 ] | Rehm, J. et al. (2010) "The relation between different dimensions of alcohol consumption and burden of disease: an overview", Addiction, 105(5), pp. 817-843. Available at: https://onlinelibrary.wiley.com/action/showCitFormats?doi=10.1111%2Fj.1360-0443.2010.02899.x (Accessed: 24 January 2022). |
[ 91 ] | Renfrew, C. (2003) “Grains, Seeds, and Fruits from Prehistoric Sitagroi” , in: E. S. Elster & C. Renfrew p. 12-15 |
[ 92 ] | Renaud, S. and de Lorgeril, M. (1992) "Wine, alcohol, platelets, and the French paradox for coronary heart disease", The Lancet, 339(8808), pp. 1523-1526. doi: 10.1016/0140-6736(92)91277-f. https://pubmed.ncbi.nlm.nih.gov/1351198/ |
[ 93 ] | Renaud, S. et al. (2004) "Alcohol and Mortality from All Causes", Biological Research, 37(2). doi: 10.4067/s0716-97602004000200002. https://www.scielo.cl/pdf/bres/v37n2/art02.pdf |
[ 94 ] | Ribéreau-Gayon, P., et al. (2006). Handbook of enology. pp.96-97 2nd ed. Willey. |
[ 95 ] | Rifler, J. et al. (2011) "A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients", Molecular Nutrition & Food Research, 56(2), pp. 345-351. doi: 10.1002/mnfr.201100336. https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201100336?saml_referrer |
[ 96 ] | Rodríguez Vaquero, M., Alberto, M. and Manca de Nadra, M. (2007) "Influence of phenolic compounds from wines on the growth of Listeria monocytogenes", Food Control, 18(5), pp. 587-593. doi: 10.1016/j.foodcont.2006.02.005. |
[ 97 ] | Roerecke, M. and Rehm, J. (2010) "Irregular Heavy Drinking Occasions and Risk of Ischemic Heart Disease: A Systematic Review and Meta-Analysis", American Journal of Epidemiology, 171(6), pp. 633-644. doi: 10.1093/aje/kwp451. |
[ 98 ] | Salazar, H. et al. (2022) "The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium", European Journal of Nutrition. doi: 10.1007/s00394-022-02823-0. |
[ 99 ] | Salehi, B. et al. (2018) "Resveratrol: A Double-Edged Sword in Health Benefits", Biomedicines, 6(3), p. 91. doi: 10.3390/biomedicines6030091. https://pubmed.ncbi.nlm.nih.gov/30205595/ |
[ 100 ] | Scheunemann et al. (2002) "Evidence for a positive association between pulmonary function and wine intake in a population-based study", Sleep & breathing = Schlaf & Atmung, 6(4), p. Available at: https://pubmed.ncbi.nlm.nih.gov/12524569/ (Accessed: 6 February 2022). |
[ 101 ] | Schriever, C., Pendland, S. and Mahady, G. (2003) "Red wine, resveratrol, Chlamydia pneumoniae and the French connection", Atherosclerosis, 171(2), pp. 379-380. doi: 10.1016/j.atherosclerosis.2003.08.026. |
[ 102 ] | Siedlinski, M. et al. (2011) "Dietary factors and lung function in the general population: wine and resveratrol intake", European Respiratory Journal, 39(2), pp. 385-391. doi: 10.1183/09031936.00184110. |
[ 103 ] | Sisson, J. (2007) "Alcohol and airways function in health and disease", Alcohol, 41(5), pp. 293-307. doi: 10.1016/j.alcohol.2007.06.003. |
[ 104 ] | Stampfer, M.J et al. (2005), "Effects of moderate alcohol consumption on cognitive function in women", New England Journal of Medicine, vol. 352, no. 3, pp. 245-253 https://www.scopus.com/record/display.uri?eid=2-s2.0-12144284532&origin=inward |
[ 105 ] | Stanton T Siu, A. (2010) "Alcohol and Lung Airways Function", The Permanente journal, 14(1), p. 11. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912709/ (Accessed: 21 February 2022). |
[ 106 ] | Tabrizi et al, (2020) "The effects of resveratrol intake on weight loss: a systematic review and meta-analysis of randomized controlled trials" , p. Available at: https://www.tandfonline.com/doi/abs/10.1080/10408398.2018.1529654?journalCode=bfsn20 (Accessed: 16 January 2022). |
[ 107 ] | Takkouche, B. (2002) "Intake of Wine, Beer, and Spirits and the Risk of Clinical Common Cold", American Journal of Epidemiology, 155(9), pp. 853-858. doi: 10.1093/aje/155.9.853. https://pubmed.ncbi.nlm.nih.gov/11978590/ |
[ 108 ] | Teissedre, P. et al. (2018) "The effects of wine consumption on cardiovascular disease and associated risk factors: a narrative review", OENO One, 52(1), pp. 67-79. doi: 10.20870/oeno-one.2018.52.1.2129. |
[ 109 ] | Teissèdret et al. (1998) "Vanadium levels in French and Californian wines: Influence on vanadium dietary intake" Food Additives & Contaminants, Volume 15, 1998 - Issue 5. Available at: https://www.tandfonline.com/doi/abs/10.1080/02652039809374685 (Accessed: 10 March 2022). |
[ 110 ] | Thun, M. et al. (1997) "Alcohol Consumption and Mortality among Middle-Aged and Elderly U.S. Adults", New England Journal of Medicine, 337(24), pp. 1705-1714. doi: 10.1056/nejm199712113372401. https://pubmed.ncbi.nlm.nih.gov/9392695/ |
[ 111 ] | Timmers, S. et al. (2011) "Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans", Cell Metabolism, 14(5), pp. 612-622. doi: 10.1016/j.cmet.2011.10.002. https://pubmed.ncbi.nlm.nih.gov/22055504/ |
[ 112 ] | Tomé-Carneiro, J. et al. (2012) One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. The American journal of cardiology, 110(3), 356–363. https://doi.org/10.1016/j.amjcard.2012.03.030 |
[ 113 ] | Tresserra-Rimbau, A. et al. (2015) "Moderate red wine consumption is associated with a lower prevalence of the metabolic syndrome in the PREDIMED population", British Journal of Nutrition, 113(S2), pp. S121-S130. doi: 10.1017/s0007114514003262 |
[ 114 ] | Truelsen, T. et al. (1998) "Intake of Beer, Wine, and Spirits and Risk of Stroke", Stroke, 29(12), pp. 2467-2472. doi: 10.1161/01.str.29.12.2467. http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.531.7267&rep=rep1&type=pdf |
[ 115 ] | Tsang, C. et al. (2005) "The influence of moderate red wine consumption on antioxidant status and indices of oxidative stress associated with CHD in healthy volunteers", British Journal of Nutrition, 93(2), pp. 233-240. doi: 10.1079/bjn20041311. https://www.scopus.com/record/display.uri?eid=2-s2.0-15944400337&origin=inward |
[ 116 ] | Valamoti, S. M. (2009) The Archaeobotanical Research of Nutrition in Prehistoric Greece, Thessaloniki 2009. pp. 93-97 |
[ 117 ] | Vally H, Thompson PJ. Role of sulfite additives in wine induced asthma: single dose and cumulative studies. Thorax 2001;56 : 763–769. |
[ 118 ] | Varoni, E. et al. (2016) "Anticancer Molecular Mechanisms of Resveratrol", Frontiers in Nutrition, 3. doi: 10.3389/fnut.2016.00008.Frontiers | Anticancer Molecular Mechanisms of Resveratrol | Nutrition (frontiersin.org) |
[ 119 ] | Vasquez, M. et al. (2018) "Persistent light to moderate alcohol intake and lung function: A longitudinal study", Alcohol, 67, pp. 65-71. doi: 10.1016/j.alcohol.2017.08.013 |
[ 120 ] | Vaz, M., Hogg, T., Couto, J.A., 2012. The antimicrobial effect of wine on Bacillus ceresus in simulated gastro-intestinal conditions. Food Control 28, 230e236 |
[ 121 ] | Vaz-da-Silva, et al. (2008). Effect of food on the pharmacokinetic profile of trans-resveratrol. International journal of clinical pharmacology and therapeutics, 46(11), 564–570. https://doi.org/10.5414/cpp46564 |
[ 122 ] | Vitaglione, et al,. (2005). Bioavailability of trans-resveratrol from red wine in humans. Molecular nutrition & food research, 49(5), 495–504. https://doi.org/10.1002/mnfr.200500002 |
[ 123 ] | Wang, J. et al. (2014) "Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications", Frontiers in Aging Neuroscience, 6. doi: 10.3389/fnagi.2014.0004 |
[ 124 ] | Wang et al. (2002) "Effect of resveratrol on platelet aggregation in vivo and in vitro", Chinese medical journal, 115(3), p. Available at: https://pubmed.ncbi.nlm.nih.gov/11940369/ (Accessed: 5 March 2022). |
[ 125 ] | Wang, D. et al. (2022) "Alcohol intake, beverage type, and lung function: a multicohort study of Chinese adults", doi: 10.1111/nyas.14744 |
[ 126 ] | World Health Organization, (2011) “Global status report on alcohol and health”, WHO Library Cataloguing-in-Publication Data https://www.who.int/substance_abuse/publications/global_alcohol_report/msbgsruprofiles.pdf |
[ 127 ] | World Health Organization, (2018) «Global status report on alcohol and health 2018» Apps.who.int. Available at: https://apps.who.int/iris/bitstream/handle/10665/274603/9789241565639-eng.pdf (Accessed: 2 November 2021). |
[ 128 ] | Zhang, T. et al. (2021) "Efficacy and Safety of Resveratrol Supplements on Blood Lipid and Blood Glucose Control in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials", Evidence-Based Complementary and Alternative Medicine, 2021, pp. 1-15. doi: 10.1155/2021/5644171 |
[ 129 ] | Zhu, W., et al. (2012). Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer. Nutrition and Cancer 64 (3): 393–400. |
[ 130 ] | Zhu, X. et al. (2017) "Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis", Nutrition & Metabolism, 14(1). doi: 10.1186/s12986-017-0217-z. |
[ 131 ] | Zhuo Fu, D. (2013) "Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes", Current diabetes reviews, 9(1), p. 25. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934755/ (Accessed: 14 January 2022). |